America’s Top 10 Selling Prescription Drugs

America’s Top 10 Selling Prescription Drugs
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1. Synthroid- 21,561,481- Abbott Laboratories- Hypothyroidism

Synthroid is a man-made genre of principle thyroid hormone that is produced by thyroid gland. The generic name for Synthroid is levothyroxine. Thyroid hormone is involved in gearing up metabolic reactions of cells of all the tissue of body. Thyroid hormone in adults is involved in growth and development of brain and bones.

Prescribed for:
Synthroid is used for the treatment of underactive thyroid (hypothyroidism). It provides or replaces thyroid hormone mainly produced by thyroid gland. Hypothyroidism can occur naturally or when the thyroid gland is destroyed by exposing it to radiations. Maintenance of normal levels of thyroid hormone is very much important for normal mental and physical activity

Synthroid is also used to treat other types of disorders such as thyroid cancers and certain types of goiters.

2. Crestor- 21,478,776- AstraZeneca – Lowers cholesterol, increases good cholesterol

Generic name for crestor is rosuvastatin. It is administered orally and is used for lowering blood cholesterol levels. It is one of the most important drugs classified under HMG-CoA reductase inhibitors which are more commonly known as statins.

Prescribed for:
Crestor is prescribed for lowering blood total cholesterol and tri-glyceride levels. It is also used for turning down the risks of stroke and heart attacks.

This drug lower cholesterol levels by inhibiting a major enzyme known as HMG-CoA reductase which is involved in hepatic (liver) synthesis of cholesterol. Crestor not only lowers blood total cholesterol but also blood LDL cholesterol levels. LDL also known as bad type of cholesterol increases the risks of coronary heart diseases. On the other hand Crestor increases HDL levels usually noted as good type of cholesterol.

3. Ventolin HFA- 18,203,939- GlaxoSmithKline- Asthma

Generic name for ventolin HFA is albuterol. It is a powerful bronchodilator that is known to relax airway muscles and to increase air flow to the lungs.

Prescribed for:
Ventolin HFA is prescribed for treating asthma. Asthma is the breathing problem that occurs due to obstruction of airways due to muscular spasm or mucus accumulation. This narrowing of muscles leads to coughing, congestion, wheezing and shortness of breath. Ventolin HFA dilates these obstructed air ways by acting as a strong bronchodilator.

Ventolin HFA is classified under the group of drugs known as bronchodilators. Ventolin HFA can also prove to be helpful in patients suffering from chronic bronchitis and emphysema when symptoms are partly similar to contracture and spasm of airway muscles.

4. Nexium- 15,298,228- AstraZeneca- Treats symptoms of gastroesophageal reflux disease

Generic name for nexium is esomeprazole. It is classified under group of drugs known as proton pump inhibitors (PPI) which are known to block acid production by stomach. Nexium is administered orally and it may take 1-4 days for full blown effect.

Prescribed for:
Nexium is prescribed for treating certain esophagus and stomach problems (such as ulcers, gastro-esophageal reflux disease (GERD). It manifests itself by decreasing the amount of acid produced by stomach. It is used for healing acid damage to stomach and esophagus. It helps to prevent ulcers and it may also prevent certain type of cancers of esophagus. It is also prescribed for Zollinger-Ellison syndrome which too is caused by stomach acid. This medication works by blocking the enzymes in the wall of stomach that are involved in the production of acids hence decreasing the amount of acid produced which in inturn heals the esophagus and stomach.

5. Advair Diskus- 13,776,325- GlaxoSmithKline- Asthma and chronic obstructive pulmonary disease (COPD)



Advair includes two major drugs fluticasone and salmeterol. Fluticasone is a well-known corticosteroid that works by reducing the swelling and irritation of air ways whereas salmeterol belongs to a group of drugs known as long acting beta agonists. It manifests itself by opening the air ways of the lungs to make breathing smooth and easier.

Prescribed for:
The medication is prescribed for asthma or on-going lung disease (chronic obstructive pulmonary disease-COPD) such as emphysema and chronic bronchitis.

Advair diskus should only be used by children and adults who are at least 4 years old. This medication must be used regularly in order to get effective results. Leave periodic intervals between each usage.

6. Lantus Solostar- 10,939,840- Sanofi- Insulin- Diabetes

(Photo by Paul Archuleta/FilmMagic

(Photo by Paul Archuleta/FilmMagic

Generic name for Lantus Solostar is insulin glargin. It is genetically engineered (man-made) and injectable form of long acting insulin that is used to modulate the blood sugar levels. This drug acts in the same way as human insulin with an action that is long lasting. It directs movement of sugar from blood to tissues while inhibiting hepatic synthesis of sugar (glucose)

Prescribed for:
Lantus Solostar is prescribed for diabetic type 1 and type 2 patients. Individuals suffering from type 2 diabetes do not produce enough insulin while diabetes type 2 patients produce very less insulin or insulin is not as efficacious owing to insulin resistance. Lantus Solostar mimics the action of natural insulin by directing the blood glucose inside tissues and at the same time stops glucose production in the body.

7. Vyvanse- 10,413,999- Shire US Inc.- ADHD

Rebecca Marie Sasnett/ The Daily Wildcat

Rebecca Marie Sasnett/ The Daily Wildcat

Generic name for vyvanse is lisdexamfetamine. It belongs to the class of drugs known as sympathomimetic amines. It is a stimulant of central nervous system. It influences chemicals in brain and nerves that play an important role in hyperactivity and impulse control.

Prescribed for:
Vyvanse is prescribed for the treatment of attention deficit hyperactivity disorder (ADHD) as a segment of total treatment plan including social, psychological and other treatments. This prescription may also help the patient to stay focused, pay attention and to stop wriggling.
Vyvanse may also be used for the treatment of binge eating disorder (BED) in case of adults. Vyvanse may help to cut short the number of binge eating days.

8. Lyrica- 10,022,365- Pfizer- Controls seizures, treats nerve pain and fibromyalgia

Generic name for lyrica is pregabalin. It is an oral medication that is used for the treatment of pain caused by neurologic diseases. This pregabalin binds to the calcium channels on the nerve membrane which may alter the release of neurotransmitters. This binding reduces the conveyance between nerves thus explaining the effect of pregabalin on pain.

Prescribed for:
This medication is prescribed for the treatment of nerve pain caused by an injury to spinal cord. Lyrica is also recommended for the patients suffering from fibromyalgia. Lyrica is also prescribed for the treatment of postherpetic neuralgia and in combination with other medication it is also used to treat seizures. Patients with nerve damage due to diabetes may also be treated with lyrica.

9. Spiriva Handihaler- 9,635,935- Pfizer- COPD

Spiriva Handihaler:
Generic name for Spiriva Handihaler is tiotropium. Spiriva is a well-known bronchodilator that increases the air flow to the lungs by relaxing the air way muscles. Spiriva is used to avert bronchospasm i.e. narrowing of airways in lungs in people suffering from chronic obstruction pulmonary disease (COPD). Spiriva is also used for treating and preventing flare-ups and worsening of COPD symptoms.

Prescribed for:
Spiriva handihaler is prescribed for treatment of chronic obstruction pulmonary disease (COPD) symptoms including bronchitis and emphysema. It works by dilating the muscle around air ways. Dilatation of air way muscles causes their opening so that you can breathe more efficaciously.
This medication is not prescribed for sudden shortness of breath because it works slowly.

10. Januvia- 9,148,946- Merck & Co.- Diabetes

Generic name for Januvia is sitagliptin. Sitagliptin belongs to the class of drugs that inhibit the enzyme dipeptidyl peptidase-4 and hence they are also known as DPP-4 inhibitors. It is an oral medicine that helps to check blood sugar levels. It maneuvers itself by modulating the amount of insulin body produces after eating.
It is mostly used in combination with other medicines.

Prescribed for:
Januvia along with proper diet programme and other medication is prescribed for the treatment of type 2 diabetes. It manifests itself by producing natural substances called incretins. These incretins help to modulate blood sugar levels by increasing insulin release, especially after every meal. This medication also inhibits the hepatic (liver) synthesis of glucose.
This medication is no longer prescribed for type 1 diabetes.